ASSOCIATION BETWEEN PERCEIVED CONTROL AND COGNITIVE FUNCTION AMONG STROKE SURVIVORS IN CHINA: A LONGITUDINAL STUDY

Abstract This study explored the association between perceived control and cognitive function among stroke survivors in China. We conducted a longitudinal study and assessed perceived control (by Perceived Control in Health Care Questionnaire) and cognitive function (by Montreal Cognitive Assessment, MoCA) of 231 stroke survivors at the acute stage, 3, 6 months after onset from two stroke centers in Shanghai and Linyi from June to December 2020. General linear mixed model was used for analysis. Perceived control was at a moderate level, and the average score of MoCA showed cognitive impairment at 3 waves. Both perceived control and cognitive function improved with time. Perceived control was positively associated with cognitive function (β=0.08, p＜0.001). After controlling for stroke severity, risk factors of cognitive impairment, age, gender, and education, the association was still significant (β=0.04, p＜0.001). These findings suggest that perceived control may be a potential target in cognitive interventions for stroke survivors.

Older adults might be more likely to experience adverse effects of opioid medications, or accidental overdose because of age-related multi-morbidities and polypharmacy. Arkansas has the second highest legal opioid prescription rate in the nation hence disseminating information to older individuals is key in fighting the opioid epidemic. As part of an Opioid Prevention for Aging and Longevity Program, we conducted a community-based, cross-sectional, anonymous survey of individuals >59 years about opioids, the common side effects and use of naloxone. The total N was 304, and the response per item varied from 236-298. Respondents' knowledge was strongest for preventative safety measures: to avoid drinking alcohol when using opioids 90.94% and to lock opioids in a secure location when children are nearby (89.49%). About three-quarters of respondents correctly identified medications classified as opioid (70.34%) or non-opioid (74.48%). Similarly, 75.36% recognized a non-opioid, ibuprofen, as the appropriate pain medication for back pain. The side effects of opioids not as well recognized. Sleepiness and trouble driving was the best understood side effect (72.18%). In contrast, the side-effect of constipation was correctly identified in just 34.17% of responses and trouble urinating in only 26.79%. In addition, a key emergency safety measure in case of opioid over-dose was far less known: Only 63.98% were able to correctly identify naloxone as an antidote for opioid overdose.Older adults exhibited gaps in knowledge about the common side effects of prescription opioids and were unaware of the life-saving role of naloxone in reversing the effects of opioid overdose. communication strategies both increased significantly with training (t(129) = -5.40 p < .001 and t(124) = -6.42 p < .001). In addition, high levels of acceptability, appropriateness, and satisfaction were reported. Findings indicate the benefits of online training for emotion-focused communication for caregivers. The discussion will focus on recommendations for practice, policy, and research. Defined as, "stereotype, prejudice, and discrimination directly towards people because of their age", ageism may contribute to adverse health outcomes, accelerate aging process, and increase the burden on health and social services. Little is known about the ageism impact on biological aging. Secondary analysis of the American Health and Retirement Study (2012 and 2016 waves) was carried out. Participants were asked: the self-perception of aging (SPA), the causes of receiving discrimination, including ageism as one of the causes, and the frequency of receiving such discrimination. The aging rate was measured using two distinct measurements: homeostatic dysregulation (using Mahalanobis distance on 44 biomarkers, n= 9934, 2016 wave) and epigenetic aging clocks (n=4018, 2016 wave). The influence of perceived ageism (current or previous waves) on the aging rate was modelled with linear models using biological aging (aka. homeostatic dysregulation and epigenetic age) as the dependent variable (outcome), ageism as the exposure, with considering confounders: sex, depressive symptom. The results show that more negative SPA, either from the previous (2012) or the same wave (2016), is associated with elevated homeostatic dysregulation (e.g. the slope increases from 1.20 to 1.34, p< 0.001, previous wave) and increasing epigenetic age (e.g. DNAm PhenoAge, the slope increases from 53.81 to 61.14, p< 0.001, current wave). The association between the ageism receiving frequency and biological aging is similar but less significant. The results demonstrate that ageism is associated with accelerated biological aging. More interventions are called to combat ageism and foster the health and wellbeing of the older adults.

DOES AGEISM ACCELERATE BIOLOGICAL AGING
Fudan University, Shanghai, Shanghai, China (People's Republic) This study explored the association between perceived control and cognitive function among stroke survivors in China. We conducted a longitudinal study and assessed perceived control (by Perceived Control in Health Care Questionnaire) and cognitive function (by Montreal Cognitive Assessment, MoCA) of 231 stroke survivors at the acute stage, 3, 6 months after onset from two stroke centers in Shanghai and Linyi from June to December 2020. General linear mixed model was used for analysis. Perceived control was at a moderate level, and the average score of MoCA showed cognitive impairment at 3 waves. Both perceived control and cognitive function improved with time. Perceived control was positively associated with cognitive function (β=0.08, p＜0.001). After controlling for stroke severity, risk factors of cognitive impairment, age, gender, and education, the association was still significant (β=0.04, p＜0.001). These findings suggest that perceived control may be a potential target in cognitive interventions for stroke survivors.

DIFFERENCES IN COMMUNITY AND PROVIDER STAKEHOLDERS' PERCEPTIONS ON BRAIN HEALTH SERVICE GAPS AND SCREENING NEEDS Annie Rhodes, Lana Sargent, and Faika Zanjani, Virginia Commonwealth University, Richmond, Virginia
Introduction: Alzheimer's Disease and Related Dementias (ADRD) management and prevention is a priority for providers and community members. Aligning perceptions regarding resources and screening supports person-centered care while addressing the increased dementia burden attributed to systemic inequity and health disparities. This project aimed to identify needs in lower-income diverse populations. Research Question: What are the differences in perceived service gaps and screening preferences for brain health and ADRD?
Methods: A convenience sample of 15 providers and 20 community stakeholders (55+) completed a 2021 survey about Richmond's service gaps and screening needs for brain health and ADRD.
Results: 40% of providers were ADRD focused, 65% of community members reported a memory concern. Overall, providers reported fewer service gaps: